| クラス |
名前 |
Binding partner |
アポトーシス |
NF-κB |
JNK/p38 |
| MAP4K |
HPK1(MAP4K1) |
Crks, Grb2, BLNK, SLP76, HS1, GRAP2, EGFR |
強調 |
活性化 |
活性化 |
| GCK(MAP4K2) |
MEKK1, TRAF2, Rab8 |
抑制 |
活性化 |
活性化 |
| NIK(MAP4K4) |
NCK, MEKK1, GBP3, RasGAP, p65DOK, b1 integrin |
|
|
活性化 |
| MAP3K |
MEKK1(MAP3K1) |
Axin, RIP, GCK, TRAF2, 14-3-3s, MKK4, JNK, hUBC9, Tax, Ras, Raf1, HAN11, HGK, GSK3b, GST M1-1 p115RhoGAP, a-actinin |
惹起 |
活性化 |
活性化 |
| MEKK2(MAP3K2) |
Rac, CDC42, PRK2, MEK5, Lad/RIBP, 14-3-3s, |
|
活性化 |
活性化 |
| MEKK3(MAP3K3) |
Rac, CDC42, MEK5, 14-3-3s, RIP |
|
活性化 |
活性化 |
| MEKK4(MAP3K4) |
Rac, CDC42 |
|
抑制 |
活性化 |
| Ask1(MAP3K5) |
DAXX, Ask2, PP5, SKRP1, JIP3, Hsp72, IGF-IR, D53L1, Akt2, TRAFs |
抑制 |
抑制 |
活性化 |
| Ask2(MAP3K6) |
Ask1 |
|
|
|
| TAK1(MAP3K7) |
TAB1, PP2Cepsiron, TAB2, TAB3, IKKs, Hgs, Ras, PAK1, JNK1, XIAP, NAIP, Nod2, Sef |
|
活性化 |
活性化 |
| c-COT(MAP3K8) |
KSR, TRAF2, NIK, ABIN2, p105 |
抑制 |
活性化 |
活性化 |
| MAP2K |
MEK1(MAP2K1) |
Raf, B-Raf, Erks, Grb10, Myc, |
抑制 |
|
|
| MEK2(MAP2K2) |
Raf, B-Raf, ERKs, KSR |
抑制 |
|
|
| MEK3,MKK3(MAP2K3) |
|
|
|
|
| MEK4,MKK2/4(MAP2K4) |
JIP3, YopJ, MEKK1, b-arrestin2 |
抑制 |
|
|
| MEK5(MAP2K5) |
|
抑制 |
|
|
| MKK6(MAP2K6) |
|
抑制 |
活性化 |
活性化 |
| MKK7(MAP2K7) |
SKRP1, JIP3 |
|
|
|
| MAPK |
ERK1 |
MEKs, IEX1 |
抑制 |
|
活性化 |
| ERK2 |
MEKs |
抑制 |
|
活性化 |
| p38, SAPK2A |
MEKs, DUSPs, HePTP, Elk1, CREB, ATF2 |
抑制 |
|
活性化 |
| ERK3 |
PKCb |
|
|
|
| p38δ |
|
|
|
|
| ERK5 |
|
抑制 |
|
|
| p38γ |
|
|
|
|
| p38β |
|
|
|
|
| JNK1 |
MAPKKs, CRK, JIPs, c-Jun, JunB, JunD, ATF2, c-Myc, PAX2, IRS1, WOX1 |
|
|
|
| JNK2 |
|
|
|
|
| JNK3 |
|
強調 |
|
|
| NIK |
NIK(MAP3K14) |
TRAF2,IKKs, Casp8/10 |
抑制 |
活性化 |
抑制 |
| IKK |
IKKα(IKK1) |
NIK,IkB, IKKs, Act1, FKBP51, CDC37/Hsp90, Vav1, Pan2, TAK1, Src, Asc |
(供給) |
活性化 |
|
| IKKβ(IKK2) |
NIK,IkB, IKKs, CDC37/Hsp90, TAK1, Asc, Act1, DBC1 |
供給 |
活性化 |
抑制 |
| IRAK |
IRAK |
TRAF6, MyD88, Pellino |
強調 |
活性化 |
活性化 |
| IRAK2 |
TRAF6, MyD88 |
|
活性化 |
|
| IRAK3 |
TRAF6, MyD88 |
|
活性/抑制 |
|
| Akt |
Akt |
SH2s, SH3s, Ask1, Smad3, Ft1 |
抑制 |
活性化 |
|
| DD |
RIP |
RAIDD,TRADD,(Fas), FADD, TRAF2, Casp8/10, FIP3, p62, RIP3, CLARP, TRIF, NKAP, EGFR, MEKK1, MEKK3, A20, FAK |
促進/抑制 |
活性化 |
活性化 |
| CARD |
RIP2,RICK |
Nod1,Nod2, CLARP, c-IAP1, TRAF-1,-5,-6, TRAF-2, casp-1, IKKg, COP, p75NTR, TLRs |
促進 |
活性化 |
活性化 |
| RAF |
Raf-1 |
Ras, MEK1, MEK2 |
供給 |
活性化 |
活性化 |
| PKC |
PKCα |
RACK |
抑制 |
活性化 |
惹起 |
| PKCβ |
RACK, ERK3, PKK |
抑制 |
活性化 |
|
| PKCγ |
|
|
|
惹起 |
| PDK |
PDK1 |
CARD11 |
|
|
|
| Src |
Tyk2 |
Vav |
|
|
|
| c-src |
SH2s , SH3s, TNFR1, CIN85, IKK |
抑制 |
|
惹起 |
| Syk |
Vav |
抑制 |
|
活性化 |
| ZAP70 |
Vav |
|
|
|
| Btk |
caveolin-1, Btk IL6ST, TLR4, 6, 9, DDR2 |
|
|
惹起 |
| Fyn |
PI3K, PTPalpha,SKAP55, SLAP-130, Csk |
惹起 |
活性化 |
|
| Lyn |
BCR, GADD34, GAP, GM-CSF Rb, IgER, PI3K, Tec, HS1 |
抑制 |
|
|
| Lck |
TCRs, SLP76, Csk |
|
|
|
| Fak |
Fak |
talin, MEKK1, RIP |
抑制 |
|
|
| クラス |
名前 |
Binding partner |
| TLR |
TLR1 |
(BLP) |
| TLR2 |
MD2, SP-A, zymosan, PGN, (L TA, BLP, LPS(?), porins, glycolipid, hsp70, hsp60), TRIF, MyD88, TRIAD3 |
| TLR3 |
(dsRNA, mRNA), TRIF, TRIAD3 |
| TLR4 |
(LPS, sHA, hsp70, hsp60, heparan sulfate proteoglycan), CD14, MD2, MyD88, TLR5, BTK, JIP3, TRIAD3, NAD(P)H oxidase |
| TLR5 |
flagellin, TLR4, TRIAD3 |
| TLR6 |
(BLP), BTK |
| TLR7 |
(ssRNA, imidazoquinolines, R-848, CpG) |
| TLR8 |
(R-848) |
| TLR9 |
(DNA,CpG), Ras, BTK, TRIAD3 |
| Adaptor |
MyD88 |
IRAK,IRAK-2, IRAK-M, IL-1R, FADD, MAL |
| TIRAP |
TLR4/MD2, MyD88, IRAK2, MAL |
| TRIF |
TLR2, TLR3, IRF3, RIP, RIP3 |
| TRAM |
TLR4, TRIF, IL1R, IRAKs, TRAF6 |
| クラス |
名前 |
Binding partner |
| TRAF |
TRAF1 |
TRADD, RIP, RICK, cIAPs, CASPER, A20, CLARP, TRAF1,2, FADD, I-TRAF/TANK, TRIP, NIK, KRC |
| TRAF2 |
A20, CLARP, TRADD, RIP, cIAPs, TRAF1, 2, 5, FADD, I-TRAF/TANK, TRIP, NIK, MEKK1, MEKK1, caveolin-1, NS5A, sphingosine kinase, Ask1, T2BP, TRIP6, PKR |
| TRAF3 |
TRAF3, I-TRAF/TANK, Act1, NIK, MIP-T3 |
| TRAF4 |
p47phox |
| TRAF5 |
TRAF5, RICK, NIK, Ask1, PKR |
| TRAF6 |
Ubc13/Uev1A, IRAK,IRAK2, IRAK-M, RICK, NIK, T6BP, KCNQ1,Tab2, TTRAP, Act1, Ask1, Pellino, MAST205 |
